Izigulana ezinokungasebenzi kakuhle kwezintso zifuna i-dialysis rhoqo, eyingozi kwaye iyingozi.Kodwa ngoku abaphandi kwiYunivesithi yaseCalifornia, eSan Francisco (UCSF) babonise ngempumelelo iprototype bioartificial kidney enokufakelwa kwaye isebenze ngaphandle kwesidingo samachiza.
Izintso zenza imisebenzi emininzi ebalulekileyo emzimbeni, eyona iphawuleka kakhulu kukuhluza ityhefu kunye nenkunkuma esegazini, kunye nokulawula uxinzelelo lwegazi, ukuxinana kwe-electrolyte kunye nolunye ulwelo lomzimba.
Ngoko ke, xa ezi zitho ziqala ukungaphumeleli, kunzima kakhulu ukuphindaphinda ezi nkqubo.Izigulana zihlala ziqala nge-dialysis, kodwa oku kuthatha ixesha kwaye akukhululeki.Isisombululo sexesha elide kukutshintshwa kwezintso, ezinokuthi zibuyisele umgangatho ophezulu wobomi, kodwa zihamba kunye nesidingo sokusebenzisa izidakamizwa ze-immunosuppressive ukukhusela imiphumo eyingozi yokugatywa.
Kwiprojekthi yezintso ze-UCSF, iqela liphuhlise intso ye-bioartificial enokuthi ifakwe kwizigulane ukwenza imisebenzi ephambili yezinto zangempela, kodwa ayifuni iziyobisi ze-immunosuppressive okanye i-blood thinners, ezihlala zifunwa.
Isixhobo sineendawo ezimbini eziphambili.Isihluzo segazi senziwe nge-silicon semiconductor membrane, enokususa inkunkuma egazini.Ngelo xesha, i-bioreactor iqulethe iiseli ze-renal tubular ezinobunjineli ezinokulawula umthamo wamanzi, ibhalansi ye-electrolyte kunye neminye imisebenzi ye-metabolic.Inwebu ikwakhusela ezi seli ekuhlaselweni yinkqubo yomzimba yokuzikhusela yomguli.
Iimvavanyo ezidlulileyo ziye zavumela ukuba ngalinye lala macandelo lisebenze ngokuzimeleyo, kodwa eli lixesha lokuqala iqela liye lavavanya ukuba basebenze kunye kwisixhobo.
Izintso ze-bioartificial ziqhagamshelwe kwimithambo emibini engundoqo esemzimbeni wesigulana – enye ithwala igazi elihluziweyo ilise emzimbeni ize enye ithwale igazi elihluziweyo ilibuyisele emzimbeni – nakwisinyi, apho inkunkuma ifakwa ngohlobo lomchamo.
Iqela ngoku lenze uvavanyo lobungqina bombono, obonisa ukuba intso ye-bioartificial isebenza kuphela phantsi koxinzelelo lwegazi kwaye ayifuni impompo okanye umthombo wamandla wangaphandle.Iiseli ze-renal tubular ziphila kwaye ziyaqhubeka nokusebenza kulo lonke uvavanyo.
Enkosi kwiinzame zabo, abaphandi kwiDyunivesithi yaseCalifornia, eSan Francisco ngoku bafumene ibhaso leKidneyX yeedola ezingama-650,000 njengomnye wabaphumeleleyo kwisigaba sokuqala sembasa yezintso ezenziweyo.
U-Shuvo Roy, umphandi okhokelayo wale projekthi, uthe: "Iqela lethu lenze intso eyenziweyo enokuxhasa ngokuzinzileyo ukulinywa kweeseli zezintso zomntu ngaphandle kokubangela ukusabela komzimba."Ngokunokwenzeka komdibaniso we-reactor, sinokugxila ekuphuculeni itekhnoloji yovavanyo olungqongqo ngakumbi lwangaphambi kweklinikhi kunye nolingo lwezonyango.