Abaphandi abavela kwiSebe lezobuNjineli beMechanical kunye ne-Aerospace (MAE) ye-Herbert Wertheim School of Engineering baye baphuhlisa uhlobo olutsha lwe-hemodialysis membrane eyenziwe nge-graphene oxide (GO), eyi-monoatomic layered material.Kulindeleke ukuba utshintshe ngokupheleleyo unyango lwe-dialysis yezintso ngomonde.Le nkqubela phambili ivumela i-microchip dialyzer ukuba incanyathiselwe eluswini lomguli.Ukusebenza phantsi koxinzelelo lwe-arterial, kuya kuphelisa impompo yegazi kunye ne-extracorporeal blood circuit, ivumela i-dialysis ekhuselekileyo kwinduduzo yekhaya lakho.Xa kuthelekiswa ne-polymer membrane ekhoyo, ukunyanzeliswa kwe-membrane yimiyalelo emibini yobukhulu obuphezulu, inokuhambelana kwegazi, kwaye akukho lula ukukala njengeembrane ze-polymer.
UNjingalwazi uKnox T. Millsaps we-MAE kunye nomphandi okhokelayo weprojekthi ye-membrane uSaeed Moghaddam kunye neqela lakhe baye baqulunqa inkqubo entsha ebandakanya ukuzimela kunye nokulungiswa kwezinto eziphathekayo kunye neekhemikhali ze-GO nanoplatelets.Le nkqubo ijika kuphela iileya ze-3 GO zibe ziindibano ze-nanosheet ezicwangciswe kakhulu, ngaloo ndlela zifezekisa ukunyanzeliswa kwe-ultra-high kunye nokukhetha."Ngokwenza inwebu ekwazi ukungeneka ngakumbi kunomlingani wayo webhayoloji, i-glomerular basement membrane (GBM) yezintso, sibonise amandla amakhulu e-nanomaterials, i-nanoengineering, kunye nokuzihlanganisa kwemolekyuli."Mogda Dr. Mu uthe.
Uphononongo lokusebenza kwe-membrane kwiimeko ze-hemodialysis luvelise iziphumo ezikhuthaza kakhulu.I-sieving coefficients ye-urea kunye ne-cytochrome-c yi-0.5 kunye ne-0.4, ngokulandelanayo, eyaneleyo kwi-dialysis yexesha elide ngelixa igcina ngaphezu kwe-99% ye-albumin;izifundo kwi-hemolysis, ukuzalisekisa ukuzalisekisa kunye nokudibanisa zibonise ukuba zifaniswa nezinto ezikhoyo ze-dialysis membrane Okanye zingcono kunokusebenza kwezinto ezikhoyo ze-dialysis membrane.Iziphumo zolu phononongo zipapashwe kwi-Advanced Materials Interfaces (ngoFebruwari 5, 2021) phantsi kwesihloko esithi "Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer".
UGqr. Moghaddam wathi: “Siye sabonisa iGO nanoplatelet eodolwe nge-odolo yemosaic ekhethekileyo yeGO nanoplatelet, eqhubela phambili kakhulu kwimigudu yeminyaka elishumi yokwenziwa kweenwebu ezisekwe kwigraphene.”Liqonga elisebenzayo elinokuphucula ukuhamba kwe-dialysis ebusuku ekhaya. ”UGqr. Moghaddam okwangoku usebenza ekuphuhliseni ii-microchips esebenzisa ii-membrane ze-GO ezintsha, eziza kusondeza uphando kwinyani yokubonelela ngezixhobo ezinxitywayo ze-hemodialysis kwizigulana ezinesifo sezintso.
Umhleli weNature (ngoMatshi 2020) wathi: “UMbutho Wezempilo Wehlabathi uqikelela ukuba bamalunga ne-1.2 yezigidi zabantu abafayo ngenxa yokungaphumeleli kwezintso nyaka ngamnye ehlabathini lonke [kwaye izehlo zesifo sezintso (ESRD) zibangelwa sisifo seswekile noxinzelelo lwegazi]….I-Dialysis Ukudityaniswa kwemida yetekhnoloji kunye nokufikeleleka kukwathetha ukuba ngaphantsi kwesiqingatha sabantu abadinga unyango banokufikelela kulo.Izixhobo ezinxitywa ngokufanelekileyo ezincinci zisisisombululo sezoqoqosho sokunyusa amazinga okusinda, ngakumbi kuphuhliso lwaseTshayina."I-membrane yethu yinxalenye ephambili yenkqubo encinci yokunxiba, ekwazi ukuvelisa umsebenzi wokucoca intso, ukuphucula kakhulu induduzo kunye nokufikeleleka emhlabeni jikelele," kusho uDkt Moghaddam.
"Inkqubela phambili enkulu kunyango lwezigulana ezine-hemodialysis kunye nokusilela kwezintso kuthintelwe yitekhnoloji ye-membrane.Itekhnoloji yeMembrane ayenzanga nkqubela phambili ebonakalayo kwiminyaka embalwa edlulileyo.Inkqubela phambili esisiseko yetekhnoloji ye-membrane ifuna ukuphuculwa kwe-dialysis yezintso.Izinto ezinokungena kakhulu nezikhethiweyo, ezifana ne-ultra-thin graphene oxide membrane ephuhliswe apha, inokutshintsha i-paradigm.I-membrane ecuthekileyo ekwaziyo ukuvuza ayinakuqonda kuphela ii-dialyzers ezincinci, kodwa kunye nezixhobo zokwenyani eziphathwayo nezinokunxitywa, ngaloo ndlela ziphucula umgangatho wobomi kunye noxilongo lwesigulana. ”UJames L. McGrath uthe uprofesa wobunjineli bezinto eziphilayo kwiYunivesithi yaseRochester kunye nomqambi weteknoloji entsha ye-silicon ye-membrane ye-ultra-thin ye-biological applications ezahlukeneyo (Indalo, i-2007).
Olu phando luxhaswe ngemali yiNational Institute of Biomedical Imaging and Bioengineering (NIBIB) phantsi kwamaZiko ezeMpilo eSizwe.Iqela likaDkt. Moghaddam libandakanya uDkt. Richard P. Rode, umlingani we-postdoctoral kwi-UF MAE, uDkt Thomas R. Gaborski (umphandi oyintloko), uDaniel Ornt, MD (umcuphi oyinqununu), kunye noHenry C weSebe le-Biomedical. Ubunjineli, iZiko leTekhnoloji yaseRochester.UGqr. Chung noHayley N. Miller.
UDkt. Moghaddam uyilungu le-UF Interdisciplinary Microsystems Group kwaye ukhokela i-Nanostructured Energy Systems Laboratory (NESLabs), umsebenzi wayo kukuphucula inqanaba lolwazi lwe-nanoengineering yezakhiwo ezisebenzayo kunye ne-micro / nanoscale transmission physics.Udibanisa izifundo ezininzi zobunjineli kunye nesayensi ukuqonda ngcono i-physics ye-micro / nano-scale transmission kunye nokuphuhlisa izakhiwo zesizukulwana esilandelayo kunye neenkqubo ezinomsebenzi ophezulu kunye nokusebenza kakuhle.
Herbert Wertheim College of Engineering 300 Weil Hall PO Box 116550 Gainesville, FL 32611-6550 Inombolo yeofisi yeofisi